The chemotherapeutic CX-5461 largely targets TOP2B and exhibits selective activity in higher-risk neuroblastomaguide RNAs in the genome-broad CRISPR screen in both a DMSO or CX-5461 taken care of CHP-134 cells. j Pre-rRNA 45?S expression in CX-5461 addressed cell strains relative to DMSO, determined by RT-qPCR with primers situated in an internal t